Neuroinflammation in fibromyalgia and CRPS is multifactorial

@article{Vasquez2016NeuroinflammationIF,
  title={Neuroinflammation in fibromyalgia and CRPS is multifactorial},
  author={Alex Vasquez},
  journal={Nature Reviews Rheumatology},
  year={2016},
  volume={12},
  pages={242-242}
}
  • A. Vasquez
  • Published 1 April 2016
  • Medicine
  • Nature Reviews Rheumatology
In his Review article (Neurogenic neuro­ inflammation in fibromyalgia and com­ plex regional pain syndrome. Nat. Rev. Rheumatol. 11, 639–648; 2015)1, Geoffrey Littlejohn ascribes neuroinflammation to a “neurogenic” origin, presumably triggered by pain and stress. However, attribution of neuro inflammation and central sensitization to a primary neurogenic origin is premature without integrating the well­documented coexistence of small intestine bacterial overgrowth (SIBO, one type of gastrointes… 

Neuroinflammation in fibromyalgia and CRPS: top-down or bottom-up?

TLDR
Research into the various observations surrounding neuroinflammation in fibromyalgia and CRPS is clearly needed, which should include establishment of the directionality of the different proposed mechanisms (top-down or bottom-up, or both), as well as more sophisticated clinical trials of proposed management strategies.

Role of inflammation in the pathogenesis and treatment of fibromyalgia

TLDR
There is evidence to support the inflammation-driven pathways in the pathogenesis of fibromyalgia, however, further research is required to fully understand the network of inflammation and its possible role in diagnosis and/or treatment of Fibromyalgia.

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

TLDR
The role of three mechanisms—autoimmunity, neuroinflammation, and small fiber neuropathy—in the pathogenesis of fibromyalgia are highlighted and the implementation of this relationship in the search for therapeutic options is considered.

Fibromyalgia and its New Lessons for Neuropsychiatry

TLDR
Better conceptualization of FM may also elucidate a neuropsychiatric understanding of how nociception, dysthymia, and suicidality co-develop and feed off one another.

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine

To our knowledge, this is the first study which investigates the induction of neuroinflammation in rats using an acidic-saline model of fibromyalgia. It is well known that the hippocampus has a

Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers

TLDR
Differences in the genome-wide expression profile of microRNAs were found among multiple tissues, indicating the involvement of distinct processes in fibromyalgia pathogenesis, and a gene-environmental interaction has been proposed as triggering mechanism.

The Effect of Blood Lactate Level on Prognosis in Patients with Hemorrhagic and Ischemic Cerebrovascular Disease

TLDR
BM examination should definitely be performed in patients aged ≥ 85 years, particularly in the event of cytopenia, unexplained anemia, and elevated ESR both for diagnostic purposes and to prolong life expectancy through administration of modified therapies depending on the performance status.

Epigenetics of muscle disorders

Role of inflammation in the pathogenesis and treatment of fibromyalgia

TLDR
There is evidence to support the inflammation-driven pathways in the pathogenesis of fibromyalgia, however, further research is required to fully understand the network of inflammation and its possible role in diagnosis and/or treatment of Fibromyalgia.

References

SHOWING 1-10 OF 13 REFERENCES

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

TLDR
The differing degrees to which neurogenic neuroinflammation might contribute to the multifactorial pathogenesis of both fibromyalgia and CRPS are highlighted, and the evidence suggesting that this mechanism is an important link between the two disorders, and could offer novel therapeutic targets is discussed.

Fibromyalgia: The gastrointestinal link

TLDR
Evidence that inflammatory bowel disease is associated with FM is contradictory, but should be looked for in patients taking concomitant steroids and medications used to manage pain, inflammation, and gastrointestinal complaints confound the management of FM.

Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome.

TLDR
The IPs in primary FM and, unexpectedly, CRPS are increased, and the implication of altered IP in the disease pathophysiology of FM and CRPS is stimulated.

Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement

TLDR
A role for mitochondrial dysfunction and oxidative stress in the headache symptoms associated with FM is suggested and CoQ10 supplementation should be examined in a larger placebo controlled trial as a possible treatment in FM.

Vitamin D and central hypersensitivity in patients with chronic pain.

TLDR
A role of low vitamin D levels for heightened central sensitivity, particularly augmented pain processing upon mechanical stimulation in chronic pain patients is suggested.

A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing

TLDR
In contrast with IBS, the degree of abnormality on breath test is greater in subjects with fibromyalgia and correlates with somatic pain, which is not dependent on the higher prevalence of an abnormal breath test.

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomised double-blind placebo-controlled study

TLDR
Short-term treatment with 2000 IU/day vitD significantly increased 25(OH)D levels in CD patients in remission and it was associated with increased LL-37 concentrations and maintenance of IP.

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

TLDR
It is demonstrated that OPA1 deficiency in an ADOA model influences N-methyl-D-aspartate (NMDA) receptor expression, which is involved in glutamate excitotoxicity and oxidative stress, and a new vicious cycle involved in neurodegeneration is proposed that includes glutamate excitement, oxidative Stress, and mitochondrial dynamics.