Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein.

@article{Gershen2015NeuroinflammationIT,
  title={Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein.},
  author={Leah D Gershen and Paolo Zanotti-Fregonara and Irene H Dustin and Jeih-San Liow and Jussi Hirvonen and William C. Kreisl and Kimberly J. Jenko and Sara K. Inati and Masahiro Fujita and Cheryl L. Morse and Chad Brouwer and Jinsoo Hong and Victor W. Pike and Sami S. Zoghbi and Robert B. Innis and William H. Theodore},
  journal={JAMA neurology},
  year={2015},
  volume={72 8},
  pages={882-8}
}
IMPORTANCE Neuroinflammation may play a role in epilepsy. Translocator protein 18 kDa (TSPO), a biomarker of neuroinflammation, is overexpressed on activated microglia and reactive astrocytes. A preliminary positron emission tomographic (PET) imaging study using carbon 11 ([11C])-labeled PBR28 in patients with temporal lobe epilepsy (TLE) found increased TSPO ipsilateral to seizure foci. Full quantitation of TSPO in vivo is needed to detect widespread inflammation in the epileptic brain… CONTINUE READING
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