Neuroinflammation in Parkinson's disease.

  title={Neuroinflammation in Parkinson's disease.},
  author={Etienne C. Hirsch and Sheela Vyas and St{\'e}phane Hunot},
  journal={Parkinsonism & related disorders},
  volume={18 Suppl 1},
Both epidemiological and genetic studies support a role of neuroinflammation in the pathophysiology of Parkinson's disease (PD). Furthermore, post mortem studies confirm the involvement of innate as well as adaptive immunity in the affected brain regions in patients with PD. Indeed, activated microglial cells and T lymphocytes have been detected in the substantia nigra of patients concomitantly with an increased expression of pro-inflammatory mediators. Preclinical investigations conducted in… CONTINUE READING


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