Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

@article{Tansey2008NeuroinflammationIP,
  title={Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?},
  author={Mal{\'u} G. Tansey and Tamy C Frank-Cannon and Melissa K. McCoy and Jae Kyung Lee and Terina N. Martinez and Fiona E McAlpine and Kelly A Ruhn and Thi Nguyet Anh Tran},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={709-17}
}
The inflammatory response in the brain associated with most chronic neurodegenerative diseases is termed neuroinflammation. Neuropathological and neuroradiological studies indicate that in certain neurodegenerative disorders neuroinflammation may be detectable years before significant loss of neurons occurs. In this review, we discuss the evidence from human studies and experimental models that implicate neuroinflammatory processes in the progressive neurodegeneration of the nigrostriatal… CONTINUE READING

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Abbracchio: To be or not to be (inflamed) - is that the question in anti-inflammatory drug therapy of neurodegenerative disorders

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