Neuroinflammation in Alzheimer's disease.

  title={Neuroinflammation in Alzheimer's disease.},
  author={Michael T Heneka and Monica J. Carson and Joseph K El Khoury and Gary E. Landreth and Frederic Brosseron and Douglas L Feinstein and Andreas H. Jacobs and Tony Wyss-Coray and Javier Vitorica and Richard M Ransohoff and Karl Herrup and Sally Ann Frautschy and Bente Finsen and Guy C Brown and Alexei Verkhratsky and Koji Yamanaka and Jari Koistinaho and Eicke Latz and Annett Halle and Gabor C Petzold and Terrence C. Town and David Morgan and Mari L Shinohara and V Hugh Perry and Clive Holmes and Nicolas G Bazan and David J. Brooks and St{\'e}phane Hunot and Bertrand Joseph and Nikolaus Deigendesch and O. V. Garaschuk and Erik W Boddeke and Charles A Dinarello and John C. S. Breitner and G. M. Cole and Douglas T Golenbock and Markus Kummer},
  journal={The Lancet. Neurology},
  volume={14 4},
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase… CONTINUE READING
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