Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress.

  title={Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress.},
  author={Nathan L Sparkman and Rodney W Johnson},
  volume={15 4-6},
The aging brain is characterized by a shift from the homeostatic balance of inflammatory mediators to a proinflammatory state. This increase in neuroinflammation is marked by increased numbers of activated and primed microglia, increased steady-state levels of inflammatory cytokines and decreases in anti-inflammatory molecules. These conditions sensitize the aged brain to produce an exaggerated response to the presence of an immune stimulus in the periphery or following exposure to a stressor… CONTINUE READING
83 Citations
48 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin - 1 receptor antagonist blocks chronic isolation - induced impairment in memory and neurogenesis

  • SD Neupert, DM Almeida, DK Mroczek
  • Neuropsycho - pharmacology
  • 2008

Neuroin - flammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

  • NL Sparkman, JB Buchanan, Heyen, J Chen, JL Beverly, RW Johnson
  • Brain Be - hav Immun
  • 2008

nitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice

  • SJ Lupien, F Maheu, M Tu, A Fiocco
  • Psychoneuroendocrinology
  • 2008

Similar Papers

Loading similar papers…