Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress.

@article{Sparkman2008NeuroinflammationAW,
  title={Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress.},
  author={Nathan L Sparkman and Rodney W Johnson},
  journal={Neuroimmunomodulation},
  year={2008},
  volume={15 4-6},
  pages={323-30}
}
The aging brain is characterized by a shift from the homeostatic balance of inflammatory mediators to a proinflammatory state. This increase in neuroinflammation is marked by increased numbers of activated and primed microglia, increased steady-state levels of inflammatory cytokines and decreases in anti-inflammatory molecules. These conditions sensitize the aged brain to produce an exaggerated response to the presence of an immune stimulus in the periphery or following exposure to a stressor… CONTINUE READING
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