Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration.

@article{Deslauriers2011NeuroinflammationAE,
  title={Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration.},
  author={Andr{\'e} M. Deslauriers and Amir Afkhami-Goli and Amber M Paul and Rakesh Kumar Bhat and Shaona Acharjee and Kristofor K Ellestad and Farshid Noorbakhsh and Marek Michalak and Christopher Power},
  journal={Journal of immunology},
  year={2011},
  volume={187 9},
  pages={4788-99}
}
Endoplasmic reticulum (ER) stress is a homeostatic mechanism, which is used by cells to adapt to intercellular and intracellular changes. Moreover, ER stress is closely linked to inflammatory pathways. We hypothesized that ER stress is an integral component of neuroinflammation and contributes to the development of neurological diseases. In autopsied brain specimens from multiple sclerosis (MS) and non-MS patients, XBP-1 spliced variant (XBP-1/s) was increased in MS brains (p < 0.05) and was… CONTINUE READING
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