Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?

@article{Barnum2012NeuroinflammationAN,
  title={Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?},
  author={Christopher J. Barnum and Mal{\'u} G{\'a}mez Tansey},
  journal={Current Neurology and Neuroscience Reports},
  year={2012},
  volume={12},
  pages={350-358}
}
  • C. BarnumM. Tansey
  • Published 12 May 2012
  • Biology
  • Current Neurology and Neuroscience Reports
Generally speaking, inflammation as a key piece to the Parkinson’s disease (PD) puzzle is a relatively new concept. Acceptance of this concept has gained ground as studies by various researchers have demonstrated the potential of mitigating nigral cell death by curtailing inflammation in animal models of PD. We propose that the significance of inflammation in PD pathology may extend beyond the nigrostriatal region. In the current review, we present an argument for this based on the Braak… 

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References

SHOWING 1-10 OF 108 REFERENCES

Modeling neuroinflammatory pathogenesis of Parkinson's disease.

Inflammation as a causative factor in the aetiology of Parkinson's disease

  • P. Whitton
  • Biology
    British journal of pharmacology
  • 2007
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the elderly, although a small proportion of PD patients develop the illness at a much younger age. In the former

Glial reactions in Parkinson's disease

  • P. McgeerE. Mcgeer
  • Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2008
This review concentrates on glial reactions in PD and indicates that an acute insult to the SN can result in a sustained local inflammation, and the α‐synuclein model indicates that a endogenous protein can induce inflammation and, when overexpressed, can lead to autosomal dominant PD.

Parkinson's disease: a dual‐hit hypothesis

It is concluded that the most parsimonious explanation for the initial events of sporadic Parkinson's disease is pathogenic access to the brain through the stomach and nose – hence the term ‘dual‐hit’.

The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease.

Data are consistent with a growing body of literature that implicates inflammatory cytokines in neural and behavioral processes and further suggests that TNF-α may be involved in the production and/or maintenance of non-motor symptoms in PD.

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

The studies suggest that loss of Parkin function increases the vulnerability of nigral DA neurons to inflammation-related degeneration, which may enable identification of early biomarkers of degeneration and aid in preclinical screening efforts to identify compounds that can halt or delay the progressive degeneration of the nigrostriatal pathway.
...