Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

@inproceedings{Gao2011NeuroinflammationA,
  title={Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease},
  author={Hui-ming Gao and Feng Zhang and Hui Zhou and Wayneho Kam and Belinda C. Wilson and Jau-Shyong Hong},
  booktitle={Environmental health perspectives},
  year={2011}
}
BACKGROUND Mechanisms whereby gene-environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson's disease (PD)-the second most common neurodegenerative disease-remain elusive. OBJECTIVE We created a two-hit [neuroinflammation and mutant α-synuclein (α-syn) overexpression] animal model to investigate mechanisms through which mutant α-syn and inflammation work in concert to mediate chronic PD neurodegeneration. METHODS We used an intraperitoneal injection of… CONTINUE READING
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