Neuroinflammation: a potential therapeutic target.

Abstract

The increased appreciation of the importance of glial cell-propagated inflammation (termed 'neuroinflammation') in the progression of pathophysiology for diverse neurodegenerative diseases, has heightened interest in the rapid discovery of neuroinflammation-targeted therapeutics. Efforts include searches among existing drugs approved for other uses, as well as development of novel synthetic compounds that selectively downregulate neuroinflammatory responses. The use of existing drugs to target neuroinflammation has largely met with failure due to lack of efficacy or untoward side effects. However, the de novo development of new classes of therapeutics based on targeting selective aspects of glia activation pathways and glia-mediated pathophysiologies, versus targeting pathways of quantitative importance in non-CNS inflammatory responses, is yielding promising results in preclinical animal models. The authors briefly review selected clinical and preclinical data that reflect the prevailing approaches targeting neuroinflammation as a pathophysiological process contributing to onset or progression of neurodegenerative diseases. The authors conclude with opinions based on recent experimental proofs of concept using preclinical animal models of pathophysiology. The focus is on Alzheimer's disease, but the concepts are transferrable to other neurodegenerative disorders with an inflammatory component.

020406020072008200920102011201220132014201520162017
Citations per Year

298 Citations

Semantic Scholar estimates that this publication has 298 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Craft2005NeuroinflammationAP, title={Neuroinflammation: a potential therapeutic target.}, author={Jeffrey M Craft and D Martin Watterson and Linda J Van Eldik}, journal={Expert opinion on therapeutic targets}, year={2005}, volume={9 5}, pages={887-900} }