Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors.

@article{Lissoni2008NeuroimmunomodulationIM,
  title={Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors.},
  author={Paolo Lissoni and Fernando Brivio and Luca A. M. Fumagalli and Giusy Messina and Luigi Vigor{\'e} and Daniela Parolini and Massimo Colciago and Franco Rovelli},
  journal={Anticancer research},
  year={2008},
  volume={28 2B},
  pages={1377-81}
}
BACKGROUND Anticancer immunity is under psychoneuroendocrine regulation, mainly via the pineal gland and brain opioid system, which may stimulate and inhibit antitumor immunity respectively. Cancer-related immuno-suppression does not depend only on functional damage of immune cells, but also on alterations of systems responsible for the neuroimmunomodulation, the most frequent of wich is a decline in blood levels of the pineal hormone melatonin (MLT). PATIENTS AND METHODS A study was… CONTINUE READING
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