Neuroimmune regulation during intestinal development and homeostasis

  title={Neuroimmune regulation during intestinal development and homeostasis},
  author={Henrique Veiga-Fernandes and Vassilis Pachnis},
  journal={Nature Immunology},
Interactions between the nervous system and immune system are required for organ function and homeostasis. Evidence suggests that enteric neurons and intestinal immune cells share common regulatory mechanisms and can coordinate their responses to developmental challenges and environmental aggressions. These discoveries shed light on the physiology of system interactions and open novel perspectives for therapy designs that target underappreciated neurological–immunological commonalities. Here we… 
Neuro-immunomodulation during intestinal development and in vivo homeostasis
These findings reveal a systemic interaction between the physiology and the openness of the new viewpoint of therapeutic design, with under estimation of the neuro-immunological commonality.
Enteric neuroimmune interactions coordinate intestinal responses in health and disease
How the ENS can regulate and be regulated by immune responses and how such interactions control whole tissue physiology are discussed are discussed.
The role of enteric glia in intestinal immunity.
Neuronal regulation of innate lymphoid cells.
Neuroimmune interactions in peripheral tissues
This review focuses on the impact of reciprocal neuroimmune interactions, focusing on the anatomy of neuronal innervation and on the neuronal regulation of immune cells in peripheral tissues, and sheds light on recent studies that explore how neuro immune interactions maximise sensing and integration of environmental aggressions, modulating immune function in health and disease.
Neuronal regulation of intestinal immune functions in health and disease
In both intestinal and extra‐intestinal diseases, alterations of autonomic nerve activity have been observed to be concurrent with the disease course, such as in inflammatory and functional bowel diseases, and neurodegenerative diseases.
Neuronal regulation of innate lymphoid cell responses.
Neuroimmune circuits in inter-organ communication
The impact of bidirectional neuroimmune interactions in tissue biology, organ physiology and embryonic development is focused on and how this fast-evolving field is redefining the tenets of inter-organ and intergenerational communications is explored.
Neuro-Immune Cell Units: A New Paradigm in Physiology.
The impact of NICUs in tissue physiology and how this fast-evolving field is driving a paradigm shift in the authors' understanding of immunoregulation and organismal physiology are focused on.


Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system.
Postnatal ENS development occurs in a different context, which is characterized by the presence of microbiota and an extensive immune system, suggesting an important role of these factors on enteric neural circuit formation and function.
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
This work has shown that events in prenatal and neonatal life orchestrate mucosal homeostasis, and several environmental factors promote the perinatal programming of the immune system, including colonization of the gut and airways by commensal microorganisms.
Multifaceted interactions between adaptive immunity and the central nervous system
The current standing of and challenging questions related to interactions between adaptive immunity and the CNS are summarized and the possible directions in which these aspects of neuroimmunology will be heading over the next decade are considered.
Neuroimmunity: Physiology and Pathology.
Appreciating the immune and nervous systems as a holistic, coordinated defense system provides both new insights into inflammation and exciting opportunities for managing acute and chronic inflammatory diseases.
Intestinal microbiota influence the early postnatal development of the enteric nervous system
The hypothesis that colonization of the bowel by intestinal microbiota influences the postnatal development of the enteric nervous system is tested.
Emerging roles for enteric glia in gastrointestinal disorders.
  • K. Sharkey
  • Biology, Medicine
    The Journal of clinical investigation
  • 2015
The role of enteric glia is highlighted in GI motility disorders and in barrier and defense functions of the gut, notably in states of inflammation, and in neurological diseases that involve the GI tract.