Neuroimmune basis of alcoholic brain damage.

@article{Crews2014NeuroimmuneBO,
  title={Neuroimmune basis of alcoholic brain damage.},
  author={Fulton T Crews and Ryan P Vetreno},
  journal={International review of neurobiology},
  year={2014},
  volume={118},
  pages={
          315-57
        }
}
Alcohol-induced brain damage likely contributes to the dysfunctional poor decisions associated with alcohol dependence. Human alcoholics have a global loss of brain volume that is most severe in the frontal cortex. Neuroimmune gene induction by binge drinking increases neurodegeneration through increased oxidative stress, particularly NADPH oxidase-induced oxidative stress. In addition, HMGB1-TLR4 and innate immune NF-κB target genes are increased leading to persistent and sensitized… CONTINUE READING

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