1,281 Citations
Neural systems underlying affective disorders
- Psychology, Biology
- 2003
Functional neuroimaging has revealed that increased metabolism may occur in the subgenual anterior cingulate gyrus in resting-state studies of depression and sad-mood induction, and Amygdala hyperactivation also is associated with affective disorders.
Orbitofrontal Cortex Function and Structure in Depression
- Psychology, BiologyAnnals of the New York Academy of Sciences
- 2007
Alterations in the functional balance between these regions and the circuits they form with anatomically related areas of the temporal lobe, striatum, thalamus, and brain stem thus may underlie the pathophysiology of mood disorders, such as major depression.
Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?
- PsychologyBipolar disorders
- 2002
The findings suggest that affective illnesses may share in common an underdeveloped or atrophied prefrontal region, leading to loss of cortical modulation of limbic emotional networks, which results in unipolar depression or cycling depending on the abnormalities of the subcortical structures involved.
Contributions from brain imaging to the elucidation of pathophysiology of bipolar disorder.
- Psychology, BiologyThe international journal of neuropsychopharmacology
- 2003
Preliminary findings from cross-sectional studies indicate anatomical, neurochemical, and functional brain abnormalities in bipolar patients in key regions involved in mood regulation, and the relationship of such abnormalities with illness phase and their clinical relevance needs further investigation.
Neuroimaging studies of bipolar depression: functional neuropathology, treatment effects, and predictors of clinical response
- Psychology, BiologyClinical Neuroscience Research
- 2002
The neuropathology of primary mood disorder.
- Psychology, BiologyBrain : a journal of neurology
- 2002
It must now be considered likely that changes in brain structure, both macroscopic and microscopic, are a feature of primary mood disorder, a fact to be taken into account when interpreting functional imaging, neuropsychological and neurochemical data.
Neuroimaging findings in major depression, suicidal behavior and aggression
- Psychology, BiologyClinical Neuroscience Research
- 2001
Comparison of prefrontal cell pathology between depression and alcohol dependence.
- Medicine, PsychologyJournal of psychiatric research
- 2003
Morphological Brain Changes in Depression
- PsychologyCNS drugs
- 2002
Assessment of the role of the reversal of structural changes in the therapeutic actions of antidepressants will require further longitudinal studies and careful comparisons between those patients with mood disorder who are treated with antidepressants and those who are not.
Cellular abnormalities in depression: evidence from postmortem brain tissue
- Biology, MedicineDialogues in clinical neuroscience
- 2004
Convergence of cellular changes at the microscopic level with neuroimaging changes detected in vivo provides a compelling integration of clinical and basic research for disentangling the pathophysiology of depression.
References
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Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression.
- Psychology, BiologyProgress in brain research
- 2000
The anatomy of mood disorders—review of structural neuroimaging studies
- Psychology, BiologyBiological Psychiatry
- 1997
Prefrontal-subcortical and limbic circuit mediation of major depressive disorder.
- Psychology, BiologySeminars in clinical neuropsychiatry
- 2001
Substantial progress has been made in elucidating the pathophysiology of major depressive disorder using functional and structural brain imaging and in structural imaging studies, decreased frontal lobe, hippocampal, and basal ganglia volumes are the most commonly reported findings.
The functional neuroanatomy of mood disorders.
- Psychology, MedicineJournal of psychiatric research
- 1997
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
- Biology, PsychologyBiological Psychiatry
- 2000
Subgenual prefrontal cortex abnormalities in mood disorders
- Psychology, BiologyNature
- 1997
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
- Psychology, BiologyCurrent Opinion in Neurobiology
- 2001
Neuropsychology of bipolar disorder
- Psychology, MedicineBritish Journal of Psychiatry
- 2001
This research has demonstrated biases for processing positive and negative stimuli in patients with mania and depression, respectively, and neuroimaging studies of the neural regions that underlie cognitive processing of affective meaning suggest the medial and orbitofrontal prefrontal cortex may be particularly involved.
Prefrontal Cortical‐Amygdalar Metabolism in Major Depression
- Psychology, BiologyAnnals of the New York Academy of Sciences
- 1999
A neural model in which dysfunction of limbic PFC structures impairs the modulation of the amygdala, leading to abnormal processing of emotional stimuli is suggested, which may compensate for this dysfunction by inhibiting pathological limbic activity.
Limbic-cortical dysregulation: a proposed model of depression.
- Psychology, BiologyThe Journal of neuropsychiatry and clinical neurosciences
- 1997
A working model of depression implicating failure of the coordinated interactions of a distributed network of limbic-cortical pathways is proposed to facilitate continued integration of clinical imaging findings with complementary neuroanatomical, neurochemical, and electrophysiological studies in the investigation of the pathogenesis of affective disorders.