Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

  title={Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration},
  author={Joanna M. Wardlaw and Eric E Smith and Geert Jan Biessels and Charlotte Cordonnier and Franz Fazekas and Richard Frayne and Richard I Lindley and John T. O'Brien and Frederik Barkhof and Oscar R. Benavente and Sandra E. Black and Carol Brayne and Monique M. B. Breteler and Hugues Chabriat and Charles DeCarli and Frank-Erik de Leeuw and Fergus Neil Doubal and Marco Duering and Nick C. Fox and Steven A. Greenberg and Vladimir Hachinski and Ingo Kilimann and Vincent C.T. Mok and Robert J. van Oostenbrugge and Leonardo Pantoni and Oliver Speck and Blossom C M Stephan and Stefan J. Teipel and Anand Viswanathan and David J Werring and Christopher P. L. H. Chen and Colin A. Smith and Mark A. van Buchem and Bo Norrving and Philip B. Gorelick and Martin Dichgans},
  booktitle={The Lancet. Neurology},
Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and… CONTINUE READING
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