Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study.

  title={Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study.},
  author={Dong Zhang and Lin Shi and Xiubao Song and Changzheng Shi and Pan Sun and Wutao Lou and Defeng Wang and Liang-ping Luo},
  journal={Quantitative imaging in medicine and surgery},
  volume={9 6},
Background Type 2 diabetes mellitus (T2DM) is characterized by notable familial aggregation involving common variants of many genes, and its heritability leads to a high prevalence in the siblings of affected individuals compared with the general population. Endophenotypes are objective, heritable, quantitative traits that appear to reflect the genetic risk for polygenic disorders at more biologically tractable levels. Based on a sibling pair design, we aimed to find the neuroimaging… 

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