Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study

@article{Whitwell2012NeuroimagingCO,
  title={Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study},
  author={Jennifer L. Whitwell and Dennis W. Dickson and Melissa E. Murray and Stephen D. Weigand and Keith A. Josephs},
  journal={The Lancet Neurology},
  year={2012},
  volume={11},
  pages={868-877}
}
BACKGROUND Three subtypes of Alzheimer's disease (AD) have been pathologically defined on the basis of the distribution of neurofibrillary tangles: typical AD, hippocampal-sparing AD, and limbic-predominant AD. Compared with typical AD, hippocampal-sparing AD has more neurofibrillary tangles in the cortex and fewer in the hippocampus, whereas the opposite pattern is seen in limbic-predominant AD. We aimed to determine whether MRI patterns of atrophy differ between these subtypes and whether… CONTINUE READING

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