Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophrenia.

@article{Wood2011NeuroimagingAT,
  title={Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophrenia.},
  author={Stephen J. Wood and Alison R. Yung and Patrick D. McGorry and Christos Pantelis},
  journal={Biological psychiatry},
  year={2011},
  volume={70 7},
  pages={619-25}
}
A new approach to understanding severe mental disorders such as schizophrenia is to adopt a clinical staging model. Such a model defines the extent of the illness such that earlier and milder phenomena are distinguished from later, more impairing features. Specifically, a clinical staging model makes three key predictions. First, pathologic measures should be more abnormal in more severe stages. Second, patients who progress between the stages should show change in these same pathologic… CONTINUE READING
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