Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.

@article{Seed2007NeurohumoralEO,
  title={Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.},
  author={Alison Seed and Roy Gardner and J. McMurray and Chris Hillier and David Murdoch and Robert J Macfadyen and Alain Bobillier and Jessica K Mann and Theresa Mcdonagh},
  journal={European journal of heart failure},
  year={2007},
  volume={9 11},
  pages={1120-7}
}
BACKGROUND Suppression of the renin-angiotensin-aldosterone system (RAAS) is therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a number of ways though an orally active renin inhibitor (RI) has never been studied before. We describe the neurohumoral effects of an RI. METHODS AND RESULTS 27 patients with NYHA class II or III CHF and an ejection fraction <or=0.35, were randomised to placebo, the ACE inhibitor ramipril or the RI aliskiren for 1 week after… CONTINUE READING
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