Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components.

Abstract

Neurogranin/RC3 is a protein that binds calmodulin and serves as a substrate for protein kinase C. Neuronally distributed in the hippocampus and forebrain, neurogranin is highly expressed in dendritic spines of hippocampal pyramidal cells, implicating this protein in long-term potentiation and in learning and memory processes. Null mutation of the… (More)

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Cite this paper

@article{Miyakawa2001NeurograninNM, title={Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components.}, author={Tsuyoshi Miyakawa and Edom Yared and Junhak Pak and Freesia L. Huang and Kuo-ping Huang and Jacqueline N. Crawley}, journal={Hippocampus}, year={2001}, volume={11 6}, pages={763-75} }