Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling.

Abstract

In neurons, neurogranin (Ng) binds calmodulin (CaM), and its binding affinity is reduced by increasing Ca2+, phosphorylation by PKC, or oxidation by oxidants. Ng concentration in the hippocampus of adult mice varied broadly (Ng+/+, 160-370 and Ng+/-, approximately 70-230 pmol/mg); the level in Ng+/+ mice is one of the highest among all neuronal CaM-binding… (More)

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@article{Huang2004NeurograninRC3EL, title={Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling.}, author={Kuo-ping Huang and Freesia L. Huang and Tino J{\"a}ger and Junfa Li and Klaus G. Reymann and Detlef Balschun}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2004}, volume={24 47}, pages={10660-9} }