• Corpus ID: 14308283

Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation.

@article{Inatani2000NeuroglycanCA,
  title={Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation.},
  author={Masaru Inatani and Hidenobu Tanihara and Atsuhiko Oohira and Yasumasa Otori and Akihiro Nishida and Megumi Honjo and Noriaki Kido and Yoshihito Honda},
  journal={Investigative ophthalmology \& visual science},
  year={2000},
  volume={41 13},
  pages={
          4338-46
        }
}
PURPOSE Neuroglycan C (NGC) is a transmembrane chondroitin sulfate proteoglycan present exclusively in central nervous system tissues. In the current study the expression pattern and characterization of NGC during the development of the retina were investigated. METHODS Expressional changes of NGC mRNAs during rat retinal development were examined by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). The localization and characterization of NGC core proteins were… 

Figures from this paper

Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C*
TLDR
The CS glycosylation was not necessary for intracellular trafficking of NGC to the cell surface at least in Neuro 2a cells, suggesting that the addition of CS chains to the NGC core protein is regulated in a manner different from that of other CS proteoglycans.
Spatiotemporal expression patterns of N-syndecan, a transmembrane heparan sulfate proteoglycan, in developing retina.
TLDR
The data show that N-syndecan is transiently expressed, primarily in retinal Neural fibers, during retinal development, indicating that it may be involved in formation of the retinal neural network.
Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats.
TLDR
Accumulation of neurocan in association with the retinal vasculature does not correlate with photoreceptor cell loss, because it was not observed in the rhodopsin mutant rats.
Neuroglycan C, a brain-specific part-time proteoglycan, with a particular multidomain structure
TLDR
Results obtained from immunohistological, cell biological and biochemical experiments suggest that NGC is involved in neuronal circuit formation in the central nervous system and the proposed functions of NGC in the brain are verified.
Differential neuroglycan C expression during retinal degeneration in Rpe65−/− mice
TLDR
During retinal degeneration in Rpe65−/− mice, NGC expression is induced in the neural retina, but not in the RPE, where NGC is expressed at highest levels.
Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain
TLDR
The expression of NGC in the human brain, mainly in the hippocampus, was studied and some observations were confirmed by conducting experiments using rat brain, and NGC‐IV, which was first found in the present study, had the shortest cytoplasmic domain among the four variants.
Chondroitin sulfate proteoglycans in the brain.
Proteoglycans in the Eye
TLDR
Soluble extracellular proteoglycans in corneal and trabecular meshwork tissues contribute to the stromal transparency in the corneaal tissues and the resistance of the aqueous humor outflow in trABecularMeshwork tissues.
Proteoglycans in retina
...
...

References

SHOWING 1-10 OF 51 REFERENCES
Identification of a nervous tissue-specific chondroitin sulfate proteoglycan, neurocan, in developing rat retina.
TLDR
The temporal and spatial regulation of expression of neurocan and its proteolytic variant during retinal development suggest that it may play a role in differentiation and neural network formation.
Spatiotemporal expression patterns of 6B4 proteoglycan/phosphacan in the developing rat retina.
TLDR
The existence of 6B4 proteoglycan/phosphacan was demonstrated in rat retina, although some biochemical parameters were different from those of the 6B 4 proteoglyca seen in brain.
Expression of proteoglycan decorin in neural retina.
TLDR
In rat ischemia-reperfusion models, the alterations in gene expression and immunohistochemical localization showed the contribution of this proteoglycan to the damage and repair processes in diseased retina.
Neurocan and phosphacan: two major nervous tissue-specific chondroitin sulfate proteoglycans.
TLDR
Through their interactions with neural cell adhesion and extracellular matrix molecules, these proteoglycans may play a major role in modulating cellAdhesion, neurite growth, and signal transduction across the plasma membrane during the development of the CNS.
Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development.
TLDR
This review mainly summarizes recent studies on the involvement of these three classes of proteoglycan in cell-cell and cell-substratum interactions during the brain development.
Neuroglycan C, a Novel Membrane-spanning Chondroitin Sulfate Proteoglycan That Is Restricted to the Brain (*)
TLDR
The sequence of the proteoglycan did not exhibit significant homology to any other known protein, indicating that the proteglycan, designated neuroglycan C, is a novel integral membrane proteogly can.
DSD-1-Proteoglycan Is the Mouse Homolog of Phosphacan and Displays Opposing Effects on Neurite Outgrowth Dependent on Neuronal Lineage
TLDR
DSD-1-PG/mouse phosphacan can have opposing effects on the process of neurite outgrowth dependent on neuronal lineage, and is identified as the mouse homolog of phosphacan, a neural rat CSPG.
...
...