Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia.

@article{Khan2006NeuroglobinoverexpressingTM,
  title={Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia.},
  author={Adil A. Khan and Yaoming Wang and Yunjuan Sun and Xiao Ou Mao and L. X. Xie and Erin P. Miles and Justin Graboski and Sylvia Yue Chen and Lisa M. Ellerby and Kunlin Jin and David Greenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 47},
  pages={
          17944-8
        }
}
Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or ischemic neuronal injury. We engineered transgenic mice that overexpress murine Ngb under the control of a chicken beta-actin promoter, resulting in enhanced Ngb expression in multiple cell types and multiple tissues, including brain and heart. In Ngb-overexpressing transgenic mice compared with wild-type… CONTINUE READING
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