Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death.

@article{Fordel2006NeuroglobinAC,
  title={Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death.},
  author={Elke Fordel and Liesbet Thijs and Wim Martinet and Marc Lenjou and Tilmann L Laufs and Dirk Van Bockstaele and L. Moens and Sylvia Dewilde},
  journal={Neuroscience letters},
  year={2006},
  volume={410 2},
  pages={146-51}
}
Although reactive oxygen species (ROS) at physiological concentrations are required for normal cell function, excessive production of ROS is detrimental to cells. Neuroglobin and cytoglobin are two globins, whose functions are still a matter of debate. A potential role in the detoxification of ROS is suggested. The influence of neuroglobin and cytoglobin on cell death after oxidative stress in human neuroblastoma SH-SY5Y cells was evaluated. Exposure of SH-SY5Y cells to paraquat or H(2)O(2… CONTINUE READING

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