Neuroglobin Expression in the Mammalian Auditory System

  title={Neuroglobin Expression in the Mammalian Auditory System},
  author={Stefan Reuss and Ovidiu Banica and Mirra Elgurt and Stephanie A. Mitz and Ursula Disque-Kaiser and Randolf Riemann and Marco Hill and Dawn V. Jaquish and Fred Koehrn and Thorsten Burmester and Thomas Hankeln and Nigel K. Woolf},
  journal={Molecular Neurobiology},
The energy-yielding pathways that provide the large amounts of metabolic energy required by inner ear sensorineural cells are poorly understood. Neuroglobin (Ngb) is a neuron-specific hemoprotein of the globin family, which is suggested to be involved in oxidative energy metabolism. Here, we present quantitative real-time reverse transcription PCR, in situ hybridization, immunohistochemical, and Western blot evidence that neuroglobin is highly expressed in the mouse and rat cochlea. For primary… CONTINUE READING