Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway

@article{Li2015NeuroglobinAB,
  title={Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway},
  author={Yu Li and Yu-bing Dai and Jie-yun Sun and Yue Xiang and Jun Yang and Song-yang Dai and Xiong Zhang},
  journal={Journal of Molecular Neuroscience},
  year={2015},
  volume={58},
  pages={28-38}
}
Excessive accumulation and deposition of amyloid-beta (Aβ) has been considered as a pivotal event in the pathogenesis of Alzheimer’s disease (AD). Neuronal apoptosis is one of the characteristics of AD, which is a possible mechanism underlying Aβ-induced neuronal neurotoxicity. Neuroglobin (Ngb) is a newly discovered vertebrate heme protein that exhibits neuroprotective functions against cell death associated with hypoxic and amyloid insult. However, until now, the exact mechanism of… CONTINUE READING
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