Neuroglobin, seven years after

  title={Neuroglobin, seven years after},
  author={Maurizio Brunori and Beatrice Vallone},
  journal={Cellular and Molecular Life Sciences},
Neuroglobin is expressed in vertebrates brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation suggests a relevant role in the nervous system, with tight structural restraints. Experiments in vivo and in vitro showed increased hypoxic stress damage upon repressing neuroglobin biosynthesis and improved recovery following overexpression. Neuroglobin shows internal heme hexacoordination, which controls oxygen affinity and kinetics. Neuroglobin… CONTINUE READING

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