Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration.

@article{Rukstalis2009Neurogenin3AM,
  title={Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration.},
  author={J. Michael Rukstalis and Joel Francis Habener},
  journal={Islets},
  year={2009},
  volume={1 3},
  pages={177-84}
}
The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3, Neurog3) is critical for the development of the endocrine cells of the islets. Either disrupted or forced expression of Ngn3 early in mouse pancreas development abrogates the formation of islets. The successive waves of Ngn3 expression that occur during the primary and secondary transitions of endocrine cell development temporally determine the four distinct endocrine cell lineages, α, β, PP, and δ cells that express glucagon… CONTINUE READING