Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms

@article{Sun2001NeurogeninPN,
  title={Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms},
  author={Yi Sun and Mireya F Nadal-Vicens and Stephanie Misono and Michael Z. Lin and Ana M. Zubiaga and Xianxing Hua and Guoping Fan and Michael E. Greenberg},
  journal={Cell},
  year={2001},
  volume={104},
  pages={365-376}
}
The mechanisms by which neural stem cells give rise to neurons, astrocytes, or oligodendrocytes are beginning to be elucidated. However, it is not known how the specification of one cell lineage results in the suppression of alternative fates. We find that in addition to inducing neurogenesis, the bHLH transcription factor neurogenin (Ngn1) inhibits the differentiation of neural stem cells into astrocytes. While Ngn1 promotes neurogenesis by functioning as a transcriptional activator, Ngn1… CONTINUE READING

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