Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity.

@article{Lee2002Neurogenin3I,
  title={Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity.},
  author={Catherine S N Lee and Nathalie Perreault and John Brestelli and Klaus H. Kaestner},
  journal={Genes & development},
  year={2002},
  volume={16 12},
  pages={1488-97}
}
The notch signaling pathway is essential for the endocrine cell fate in various tissues including the enteroendocrine system of the gastrointestinal tract. Enteroendocrine cells are one of the four major cell types found in the gastric epithelium of the glandular stomach. To understand the molecular basis of enteroendocrine cell development, we have used gene targeting in mouse embryonic stem cells to derive an EGFP-marked null allele of the bHLH transcription factor, neurogenin 3 (ngn3). In… CONTINUE READING
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