Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

  title={Neurogenin 2 controls cortical neuron migration through regulation of Rnd2},
  author={Julian Ik-Tsen Heng and Laurent Nguyen and Diogo S Castro and C{\'e}line Zimmer and Hendrik Wildner and Olivier Armant and Dorota Skowronska-Krawczyk and Francesco Bedogni and Jean-Marc Matter and Robert F Hevner and François Guillemot},
Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 (ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
126 Citations
34 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 126 extracted citations


Publications referenced by this paper.
Showing 1-10 of 34 references

Characterization of the proneural gene regulatory network during mouse telencephalon development

  • Gohlke, M J.
  • BMC Biol. 6,
  • 2008

Similar Papers

Loading similar papers…