Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state.

@article{Basak2012NeurogenicSZ,
  title={Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state.},
  author={Onur Basak and Claudio Giachino and Emma Fiorini and H Robson Macdonald and Verdon Taylor},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 16},
  pages={5654-66}
}
The adult mammalian forebrain contains neural stem/progenitor cells (NSCs) that generate neurons throughout life. As in other somatic stem cell systems, NSCs are proposed to be predominantly quiescent and proliferate only sporadically to produce more committed progeny. However, quiescence has recently been shown not to be an essential criterion for stem cells. It is not known whether NSCs show differences in molecular dependence based on their proliferation state. The subventricular zone (SVZ… CONTINUE READING

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