Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

@article{Littlejohn2015NeurogenicNI,
  title={Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome},
  author={Geoffrey Owen Littlejohn},
  journal={Nature Reviews Rheumatology},
  year={2015},
  volume={11},
  pages={639-648}
}
  • G. Littlejohn
  • Published 1 November 2015
  • Medicine, Psychology
  • Nature Reviews Rheumatology
Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both be triggered by specific traumatic events, although fibromyalgia is most commonly associated with psychological trauma and CRPS is most often associated with physical trauma, which is frequently deemed routine or minor by the patient… 
Neuroinflammation in fibromyalgia and CRPS is multifactorial
In his Review article (Neurogenic neuro­ inflammation in fibromyalgia and com­ plex regional pain syndrome. Nat. Rev. Rheumatol. 11, 639–648; 2015)1, Geoffrey Littlejohn ascribes neuroinflammation to
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PATHOGENESIS OF FIBROMYALGIA IN PATIENTS WITH AUTOIMMUNE DISEASES: SCOPING REVIEW FOR HYPOTHESIS GENERATION
TLDR
Fibromyalgia is the common phenotype arising from the amalgamation of various aetiologies, and recruitment or amplification of the above 6 factors by various rheumatic diseases may thus lead precipitation of secondary FM in susceptible individuals.
Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET.
TLDR
This report is the first to describe abnormal neuroinflammation levels in the brains of FM patients compared with that in patients with CRPS using [11C]-(R)-PK11195 PET, and suggested that abnormal neuro inflammation can be an important pathological factor in FM.
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