Neurogenic genes and vertebrate neurogenesis.

  title={Neurogenic genes and vertebrate neurogenesis.},
  author={Julian Lewis},
  journal={Current opinion in neurobiology},
  volume={6 1},
  • Julian Lewis
  • Published 1996 in Current opinion in neurobiology
The neurogenic genes of the Delta-Notch signalling pathway mediate lateral inhibition--a mechanism that controls cell commitment in many tissues and serves in the developing nervous system to single out cells for a neural fate. Recent work has revealed the outlines of the signal transduction pathway from Notch to the nucleus, has clarified the mechanisms by which lateral inhibition causes adjacent cells to become different, and has shown that vertebrates use essentially the same lateral… CONTINUE READING
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