Neurogenic diabetes insipidus: management with dDAVP (1-desamino-8-D arginine vasopressin).

  title={Neurogenic diabetes insipidus: management with dDAVP (1-desamino-8-D arginine vasopressin).},
  author={W E Cobb and S V Spare and Seymour Reichlin},
  journal={Annals of internal medicine},
  volume={88 2},
We used dDAVP, the 1-desamino-8-D arginine analogue of arginine vasopressin with high antidiuretic and low vasopressor potency, to treat 29 patients with neurogenic diabetes insipidus for up to 22 months. Intranasal dDAVP, 2.5 to 15 microgram twice daily, provided excellent control in most patients. Individual responses were independent of age, weight, and severity of diabetes insipidus. Resistance to dDAVP may be a rare complication of prolonged therapy. Two patients with acute postoperative… CONTINUE READING

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