Neurogenic components of trypsin‐ and thrombin‐induced inflammation in rat skin, in vivo

@article{Obreja2006NeurogenicCO,
  title={Neurogenic components of trypsin‐ and thrombin‐induced inflammation in rat skin, in vivo},
  author={Otilia Obreja and Roman Rukwied and Martin Steinhoff and Martin Schmelz},
  journal={Experimental Dermatology},
  year={2006},
  volume={15}
}
Abstract:  Activation of protease‐activated receptors (PAR) can induce vasodilation (VD) and increase of vascular permeability either directly by stimulating endothelial cells or indirectly via activation of nociceptors and subsequent release of neuropeptides (neurogenic inflammation). We aimed to estimate the relative contribution of the two pathways for stimulation with endogenous activators of PAR‐2 (trypsin) and of PAR‐1, 3 and 4 (thrombin) using in vivo dermal microdialysis in rats… Expand
The timecourse of neurogenic inflammation and the effect of modulatory agents.
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INDUCTION OF INFLAMMATORY CYTOKINE RELEASE FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY AGONISTS OF PROTEINASE‐ACTIVATED RECEPTOR‐2
TLDR
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Protease Activated Receptors and Arthritis
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