Neurogenic Model of Migraine

@article{Buzzi1995NeurogenicMO,
  title={Neurogenic Model of Migraine},
  author={M. Gabriella Buzzi and Michela Bonamini and MA Moskowitz},
  journal={Cephalalgia},
  year={1995},
  volume={15},
  pages={277 - 280}
}
Activation of peripheral trigeminal fibers induces neurogenic inflammation in rat dura mater, as well as vascular and mast cell changes. These changes parallel an increase of vasodilating and permeability promoting peptides in venous effluent of the cephalic circulation. The experimental model of electrical trigeminal ganglion stimulation or systemic capsaicin administration has proven effective in detecting cellular activation in brainstem trigeminal nuclei. Animal experimental models of… 
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109 Citations

Neurogenic inflammation in primary headaches

TLDR
The evidence in support of the hypothesis that a sterile neurogenic inflammation in the meninges may be involved in generating or sustaining, via occurrence of a vicious cycle, the pain accompanying the migraine attacks is reviewed.

Dural vasodilation causes a sensitization of rat caudal trigeminal neurones in vivo that is blocked by a 5‐HT1B/1D agonist

TLDR
Data show that dilation of meningeal blood vessels causes a sensitization of central trigeminal neurones and a facilitation of facial sensory processing which was blocked by activation of pre‐synaptic 5‐HT1B/1D receptors.

Neurogenic Vascular Responses in the Dura Mater and their Relevance for the Pathophysiology of Headaches

Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascular permeability in cochlear and vertebro-basilar arteries: a potential cause of inner ear dysfunction in headache

Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion

TLDR
Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglions cells, which might be of importance in the pathogenesis of migraine headache.

TRPV1 in migraine pathophysiology.

Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine.

TLDR
It is clear that PACAP plays an excitatory role in migraine, but its target and signalling pathways have not yet been elucidated due to the lack of non-peptide, selective agonists and antagonists.

Spontaneous Trigeminal Allodynia in Rats: A Model of Primary Headache

TLDR
This model can be used as a predictive model for drug development and for studies of putative biomarkers for headache diagnosis and treatment, and to validate this as a model for migraine.

The pathophysiology of migraine: year 2005

TLDR
It is possible that visual, motor or sensory aura might be responsible for the generation of the pain through the above mechanisms of cortical spreading depression underlies migraine.

The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches

TLDR
Evidence that supports the critical involvement of transient receptor potential (TRP) channels in the pathophysiology of primary headaches is focused on and it is suggested that the activation level of this complex may explain some of the specific features of migraine headache.
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References

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TLDR
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  • W. Sweet
  • Medicine
    Clinical neurosurgery
  • 1976
I describe the results of retrogasserian differential lidocaine block to aid in the selection of patients for a differential thermal lesion in the trigeminal ganglion and rootlets. This procedure…

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TLDR
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