Neurogenic Model of Migraine
@article{Buzzi1995NeurogenicMO, title={Neurogenic Model of Migraine}, author={M. G. Buzzi and M. Bonamini and M. Moskowitz}, journal={Cephalalgia}, year={1995}, volume={15}, pages={277 - 280} }
Activation of peripheral trigeminal fibers induces neurogenic inflammation in rat dura mater, as well as vascular and mast cell changes. These changes parallel an increase of vasodilating and permeability promoting peptides in venous effluent of the cephalic circulation. The experimental model of electrical trigeminal ganglion stimulation or systemic capsaicin administration has proven effective in detecting cellular activation in brainstem trigeminal nuclei. Animal experimental models of… CONTINUE READING
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References
SHOWING 1-10 OF 32 REFERENCES
5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation
- Chemistry, Medicine
- Brain Research
- 1992
- 94
The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
- Medicine
- Annals of neurology
- 1993
- 910
Ergot alkaloids block neurogenic extravasation in dura mater: Proposed action in vascular headaches
- Medicine
- Annals of neurology
- 1988
- 169
Enrichment of a vasoactive neuropeptide (calcitonin gene related peptide) in the trigeminal sensory projection to the intracranial arteries
- Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1988
- 142
- PDF
Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion
- Medicine
- Neuropharmacology
- 1991
- 296
Cluster Headache: Ultrastructural Evidence for Mast Cell Degranulation and Interaction with Nerve Fibres in the Human Temporal Artery
- Medicine
- Cephalalgia : an international journal of headache
- 1990
- 39
Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells
- Biology, Medicine
- Neuroscience
- 1991
- 280