Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism

@article{Bon1999NeurogeneticCO,
  title={Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism},
  author={Mauro. Bon and Ernst Jansen Steur and Robert A.I. de Vos and Istv{\'a}n Vermes},
  journal={Neuroscience Letters},
  year={1999},
  volume={266},
  pages={149-151}
}
Brain tissue of 50 patients with morphological confirmed Parkinson's disease (PD), blood samples from 149 patients with clinical parkinsonism and from 96 healthy control subjects were collected. Apolipoprotein-E (apo E) and cytochrome P450 2D6 (CYP2D6) genotyping were performed by PCR followed by restriction fragment analysis. A significantly higher allele frequency of CYP2D6*4 was found in patients with PD (35%) but not with parkinsonism (14.1%) compared to control subjects (19.8%). The… CONTINUE READING

Citations

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TETRAHYDROISOQUINOLINE NEUROTOXINS AND PARKINSON DISEASE

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Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology.

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