Neurogenesis in the adult brain: death of a dogma

  title={Neurogenesis in the adult brain: death of a dogma},
  author={Charles G. Gross},
  journal={Nature Reviews Neuroscience},
  • C. Gross
  • Published 1 October 2000
  • Biology
  • Nature Reviews Neuroscience
For over 100 years a central assumption in the field of neuroscience has been that new neurons are not added to the adult mammalian brain. This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse. The acceptance of adult neurogenesis may be part of a contemporary paradigm shift in our view of the plasticity and stability of the adult brain. 

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  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2002
Here, the available evidence is reviewed, and the scientific basis of the claim that continuous genesis and turnover of neurons in the adult primate association neocortex is questioned is questioned.

Frontiers in Neurogenesis

One of the most intriguing dogmas in neurosciences—the empirical lack of brain neuronal regeneration in adulthood onwards to late life—began to be debunked initially by research groups focused on understanding postnatal neurodevelopmental and neuroplastic events.

Adult Hippocampal Neurogenesis in Mammals (and Humans): The Death of a Central Dogma in Neuroscience and its Replacement by a New Dogma

  • R. Oppenheim
  • Biology, Psychology
    Developmental neurobiology
  • 2019
The review is a critical appraisal of the history and present status of the phenomenon of adult hippocampal neurogenesis (AHN) in the mammalian and human brain. Previous as well as most current

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This article investigates the ways in which neurogenesis in the adult brain has changed from being negated to being accepted and highly valued, and consequently has become the focus of a novel research field.

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Comparative data is examined suggesting that adult neurogenesis may play a role in certain forms of learning, and neural activity associated with behavioral experience may shape neural networks by directing the production and connectivity of whole cell populations.

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  • D. R. KornackP. Rakic
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
This demonstration of adult neurogenesis in nonhuman Old World primates-with their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities-establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogen Genesis in humans and offers new insights into its significance in the adult brain.

Neurogenesis in the adult human hippocampus

It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.

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In primates, prefrontal, inferior temporal, and posterior parietal cortex are important for cognitive function. It is shown that in adult macaques, new neurons are added to these three neocortical

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Autoradiograms from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons, suggesting a stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime.

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Two studies examine how experience regulates neurogenesis in the adult rodent hippocampus. Although their conclusions appear contradictory, they may in fact be reconcilable.

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    Annals of the New York Academy of Sciences
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The background to this work, using canaries, and the most recent findings suggest that neuronal replacement in adulthood is a form of brain repair, though it happens in the absence of an external lesion.

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It is shown that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons, indicating that the neuronal precursor population in the dentate gyrus remains stable into old age, but that neurogenesis is normally slowed by high levels of Corticosteroids.

More hippocampal neurons in adult mice living in an enriched environment

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