Neurogenesis impairment: An early developmental defect in Down syndrome

@article{Stagni2018NeurogenesisIA,
  title={Neurogenesis impairment: An early developmental defect in Down syndrome},
  author={Fiorenza Stagni and Andrea Giacomini and Marco Emili and Sandra Guidi and Renata Bartesaghi},
  journal={Free Radical Biology and Medicine},
  year={2018},
  volume={114},
  pages={15–32}
}
ABSTRACT Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting from early life stages. Accumulating evidence shows that the phenotypic features of the DS brain can be traced back to the fetal period since the DS brain exhibits proliferation potency reduction starting from the critical time window of fetal neurogenesis. This defect is worsened by the fact that neural progenitor cells exhibit reduced acquisition of a neuronal phenotype and an increase in the… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Down syndrome

Down syndrome and infertility: what support should we provide?

VIEW 2 EXCERPTS
CITES BACKGROUND

New approaches to studying early brain development in Down syndrome

VIEW 1 EXCERPT
CITES BACKGROUND

Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

VIEW 1 EXCERPT
CITES BACKGROUND

Down syndrome: From development to adult life to Alzheimer disease.

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 189 REFERENCES

Relationship Between Brain and Cognitive Processes in Down Syndrome

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Fetal transcerebellar diameter in Down syndrome.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL