Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients

  title={Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients},
  author={P. Steinacker and E. Feneberg and Jochen H Weishaupt and J. Brettschneider and H. Tumani and P. Andersen and C. V. von Arnim and Sarah B{\"o}hm and J. Kassubek and C. Kubisch and D. Lul{\'e} and H. M{\"u}ller and R. Muche and E. Pinkhardt and Patrick Oeckl and A. Rosenbohm and S. Anderl-Straub and A. Volk and P. Weydt and A. Ludolph and M. Otto},
  journal={Journal of Neurology, Neurosurgery & Psychiatry},
  pages={12 - 20}
  • P. Steinacker, E. Feneberg, +18 authors M. Otto
  • Published 2015
  • Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • Objectives Biomarkers for the diagnosis of motoneuron diseases (MND) are urgently needed to improve the diagnostic pathway, patient stratification and monitoring. The aim of this study was to validate candidate markers for MND in cerebrospinal fluid (CSF) and specify cut-offs based on large patient cohorts by especially considering patients who were seen under the initial differential diagnosis (MND mimics). Methods In a prospective study, we investigated CSF of 455 patients for neurofilament… CONTINUE READING
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