Neurofilaments as biomarkers in neurological disorders

@article{Khalil2018NeurofilamentsAB,
  title={Neurofilaments as biomarkers in neurological disorders},
  author={M. Khalil and C. Teunissen and M. Otto and F. Piehl and M. Sormani and T. Gattringer and C. Barro and L. Kappos and M. Comabella and F. Fazekas and A. Petzold and K. Blennow and H. Zetterberg and J. Kuhle},
  journal={Nature Reviews Neurology},
  year={2018},
  volume={14},
  pages={577-589}
}
  • M. Khalil, C. Teunissen, +11 authors J. Kuhle
  • Published 2018
  • Medicine
  • Nature Reviews Neurology
  • Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate… CONTINUE READING
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    References

    SHOWING 1-10 OF 134 REFERENCES
    Serum neurofilament light chain: a biomarker of neuronal injury in vasculitic neuropathy
    • 20
    Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis
    • 121
    Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients
    • 152
    Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS
    • 53