Neurofilaments as biomarkers in neurological disorders

  title={Neurofilaments as biomarkers in neurological disorders},
  author={M. Khalil and C. Teunissen and M. Otto and F. Piehl and M. Sormani and T. Gattringer and C. Barro and L. Kappos and M. Comabella and F. Fazekas and A. Petzold and K. Blennow and H. Zetterberg and J. Kuhle},
  journal={Nature Reviews Neurology},
  • M. Khalil, C. Teunissen, +11 authors J. Kuhle
  • Published 2018
  • Medicine
  • Nature Reviews Neurology
  • Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate… CONTINUE READING
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