Neurofilaments as biomarkers in neurological disorders
@article{Khalil2018NeurofilamentsAB, title={Neurofilaments as biomarkers in neurological disorders}, author={M. Khalil and C. Teunissen and M. Otto and F. Piehl and M. Sormani and T. Gattringer and C. Barro and L. Kappos and M. Comabella and F. Fazekas and A. Petzold and K. Blennow and H. Zetterberg and J. Kuhle}, journal={Nature Reviews Neurology}, year={2018}, volume={14}, pages={577-589} }
Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate… CONTINUE READING
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References
SHOWING 1-10 OF 134 REFERENCES
Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
- Medicine
- PloS one
- 2013
- 253
- PDF
CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
- Medicine
- Multiple sclerosis
- 2013
- 65
Serum neurofilament light chain: a biomarker of neuronal injury in vasculitic neuropathy
- Medicine
- Annals of the rheumatic diseases
- 2018
- 20
Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis
- Medicine
- Annals of neurology
- 2016
- 119
Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis
- Medicine
- Brain : a journal of neurology
- 2018
- 133
- PDF
Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients
- Medicine
- Journal of Neurology, Neurosurgery & Psychiatry
- 2015
- 150
Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS
- Medicine
- Amyotrophic lateral sclerosis & frontotemporal degeneration
- 2016
- 52
Elevated Concentrations of Neurofilament Light Chain in the Cerebrospinal Fluid of Bipolar Disorder Patients
- Medicine
- Neuropsychopharmacology
- 2014
- 39
- PDF