Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport

@article{Marszalek1996NeurofilamentSN,
  title={Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport},
  author={Joseph R. Marszalek and Toni L. Williamson and Michael K.S. Lee and Zuoshang Xu and Paul Ned Hoffman and Mark W. Becher and Thomas O. Crawford and Don W Cleveland},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={711 - 724}
}
To examine the mechanism through which neurofilaments regulate the caliber of myelinated axons and to test how aberrant accumulations of neurofilaments cause motor neuron disease, mice have been constructed that express wild-type mouse NF-H up to 4.5 times the normal level. Small increases in NF-H expression lead to increased total neurofilament content and larger myelinated axons, whereas larger increases in NF-H decrease total neurofilament content and strongly inhibit radial growth… CONTINUE READING

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