Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area.

@article{BeitnerJohnson1992NeurofilamentPA,
  title={Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area.},
  author={D B Beitner-Johnson and Xavier Vidal Guitart and Eric J Nestler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 6},
  pages={2165-76}
}
The ventral tegmental area (VTA) and its dopaminergic projections appear to mediate some of the rewarding properties of opiates, cocaine, and other drugs of abuse. In a previous study, we demonstrated that chronic morphine and cocaine exert common actions on tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, in this dopaminergic brain reward region (Beitner-Johnson and Nestler, 1991). In the present study, we investigated the effects of chronic morphine and cocaine on… CONTINUE READING

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Chronic morphine impairs axonal transport in the rat mesolimbic dopamine system

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1 Excerpt

1991 b) Lewis and Fischer 344 rats and drug addiction: behavioral and biochemical correlates

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