Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

@article{Petzold2005NeurofilamentPS,
  title={Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss},
  author={Axel Petzold},
  journal={Journal of the Neurological Sciences},
  year={2005},
  volume={233},
  pages={183-198}
}
  • A. Petzold
  • Published 15 June 2005
  • Biology, Medicine
  • Journal of the Neurological Sciences
Neurofilaments : A Biomarker for Axonal Degeneration
2 Definitions  Neurofilaments: Nf are proteins which are exclusively expressed in neurons and their adjacent axons. Nf are particularly abundant in the axon, where they are key building blocks of
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SERUM PHOSPHORYLATED NEUROFILAMENT HEAVY CHAIN AS A MARKER OF AXONAL INJURY AND DISEASE SEVERITY IN MULTIPLE SCLEROSIS PATIENTS
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The highest levels of proteins were in the secondary progressive MS and these levels significantly correlated with disease severity measured by EDSS.
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The structure, normal function and molecular pathology of neurofilaments are discussed and neurofilament mutations associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis are discussed.
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The results suggest that axonal damage occurs during relapsing-remitting multiple sclerosis and that the damage contributes to disability and the appearance of clinical exacerbations.
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TLDR
Immunohistochemical staining demonstrated ohosphorylated neurofilament antigen within the cytoplasm of the chromatolytic neurons, suggesting that a defect in slow axonal transport or in the regulation of neurofilaments phosphorylation may play a role in the pathogenesis of Werdnig-Hoffman disease.
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