Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

  title={Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss},
  author={A. Petzold},
  journal={Journal of the Neurological Sciences},
  • A. Petzold
  • Published 2005
  • Biology, Medicine
  • Journal of the Neurological Sciences
  • This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the… CONTINUE READING
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