Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

@article{Petzold2005NeurofilamentPS,
  title={Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss},
  author={A. Petzold},
  journal={Journal of the Neurological Sciences},
  year={2005},
  volume={233},
  pages={183-198}
}
  • A. Petzold
  • Published 2005
  • Biology, Medicine
  • Journal of the Neurological Sciences
  • This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the… CONTINUE READING
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    References

    SHOWING 1-10 OF 162 REFERENCES
    Neurofilaments and neurological disease.
    • A. Al-Chalabi, C. Miller
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2003
    • 164
    Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis
    • 238
    • PDF
    Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS
    • 68
    • Highly Influential
    Elevated neurofilament levels in neurological diseases
    • 268
    • Highly Influential
    Spinal cord trauma in man: studies of phosphorylated neurofilament and ubiquitin expression.
    • 33
    Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia
    • 81
    Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit
    • 135
    • Highly Influential
    Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.
    • 73
    • PDF
    Neurofilament functions in health and disease
    • J. Julien
    • Biology, Medicine
    • Current Opinion in Neurobiology
    • 1999
    • 206