Neurofilament light chain as a biomarker in neurological disorders

@article{Gaetani2019NeurofilamentLC,
  title={Neurofilament light chain as a biomarker in neurological disorders},
  author={L. Gaetani and K. Blennow and P. Calabresi and M. Di Filippo and L. Parnetti and H. Zetterberg},
  journal={Journal of Neurology, Neurosurgery, and Psychiatry},
  year={2019},
  volume={90},
  pages={870 - 881}
}
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic… Expand
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