Neurofilament and tubulin transport slows along the course of mature motor axons

@article{Watson1989NeurofilamentAT,
  title={Neurofilament and tubulin transport slows along the course of mature motor axons},
  author={D. F. Watson and Paul Ned Hoffman and K P Fittro and John Wesley Griffin},
  journal={Brain Research},
  year={1989},
  volume={477},
  pages={225-232}
}
The rate of axonal transport of tubulin and of neurofilament proteins was measured in mature, non-growing, axons of rat lumbar ventral roots and sciatic nerves. A progressive decrease in the velocity of transport was observed along the course of the axons. The rate of advance of the 'front' of labeled neurofilaments decreased from 1.40 +/- 0.07 mm/day proximally to 0.64 +/- 0.04 mm/day distally. The rate for tubulin decreased from 3.10 +/- 0.13 proximally to 1.01 +/- 0.04 mm/day distally. These… CONTINUE READING

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