Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

  title={Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases},
  author={Mehtap Bacioglu and Lu{\'i}s Fernando Monsores Passos Maia and Oliver Preische and Juliane Schelle and Anja Apel and Stephan A. Kaeser and Manuel Schweighauser and Timo Eninger and Marius Lambert and Andrea Pilotto and Derya R. Shimshek and Ulf Neumann and Philipp J Kahle and Matthias Staufenbiel and Manuela Neumann and Walter Maetzler and Jens Kuhle and Mathias Jucker},
A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To monitor such treatments, fluid biomarkers reflecting the underlying disease process are crucial. We found robust increases of neurofilament light chain (NfL) in CSF and blood in murine models of α-synucleinopathies, tauopathy, and β-amyloidosis. Blood and CSF NfL levels were strongly correlated, and NfL increases… CONTINUE READING


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