Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo.

@article{Dasgupta2005NeurofibrominRN,
  title={Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo.},
  author={Biplab Dasgupta and David H Gutmann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 23},
  pages={5584-94}
}
Neurofibromatosis 1 (NF1) is a common inherited disease in which affected children exhibit abnormalities in astrocyte growth regulation and are prone to the development of brain tumors (astrocytoma). Previous studies from our laboratory demonstrated that Nf1 mutant mouse astrocytomas contains populations of proliferating nestin+ progenitor cells, suggesting that immature astroglial progenitors may serve as a reservoir of proliferating tumor cells. Here, we directly examined the consequences of… CONTINUE READING