Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.

@article{Li2006NeurofibrominIA,
  title={Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.},
  author={Fang Li and Amy M Munchhof and Hilary A White and Laura E. Mead and Theresa R Krier and Amy Fenoglio and Shi Chen and Xiaohua Wu and Shanbao Cai and Fengchun Yang and David A. Ingram},
  journal={Human molecular genetics},
  year={2006},
  volume={15 11},
  pages={1921-30}
}
Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin is encoded by NF1 and functions as a negative regulator of Ras activity. NF1 patients develop renal artery stenosis and arterial occlusions resulting in cerebral and visceral infarcts. Further, NF1 patients develop vascular neurofibromas where tumor vessels are invested in a dense pericyte sheath. Although it is well established that aberrations in Ras signaling lead to human… CONTINUE READING
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